(Alkaloid)

Suprax(various products)

Ceforal

(Astellas)

Amoxicillin DS(Mecofar Chemical-Pharmaceutical)

Amosin

(Synthesis OJSC)

Flemoxin

Solutab

(Astellas)

Hikoncil(Krka)

Amoxiclav Quiktab

Augmentin

(GlaxoSmithKline)

panclave

(Hemofarm)

Flemoklav Solutab(Astellas)

Ecoclave

(Avva Rus)

Azitral(Shreya)

Azitrox

(Pharmstandard)

Azicide

(Zentiva)

Zetamax

retard (Pfizer)

Z-factor

(Veropharm)

Zitrolide

(Valens)

Zitrolide forte(Valens)

Sumamed

(Teva, Pliva)

Sumamed forte(Teva, Pliva)

Hemomycin

(Hemofarm)

Ecomed

(Avva Rus)

Klabaks

(Ranbaxi)

Clubax OD (Ranbaxi)

Klacid(Abbott)

Klacid SR

Fromilid(Krka)

Fromilid Uno(Krka)

Ecositrin

(Avva Rus)

Zanocin

(Ranbaxi)

Zanocin OD(Ranbaxi)

Zoflox

(Mustafa nevzat ilach sanai)

Ofloksin

(Zentiva)

Tarivid(Sanofi-Aventis)

Tsiprinol(Krka)

Tsiprobay(Bayer)

Tsiprolet

(Dr. Reddy's)

Tsipromed

Cifran

(Ranbaxi)

Digital OD(Ranbaxi)

Ecocyfol

(Avva Rus)

In our time, the question of the choice of antibiotics is quite acute. With each passing day, the resistance of microorganisms to drugs is growing, and it is becoming increasingly difficult to choose the right one. Thanks to modern technologies, new groups of antibiotics are being discovered, as well as modifying and supplementing existing types.

Levofloxacin

Levofloxacin is a fully synthetic agent belonging to the group fluoroquinolones. The substance has a wide spectrum of action, therefore it can be used for most known infections, and also as a preliminary therapy in a period when the exact pathogen is not identified.

Levofloxacin is available in three forms: oral tablets, injection, and eye drops. The choice of form is made on the basis of the localization of the infection, as well as its severity.

The mechanism of action of levofloxacin is based on the inhibition of the main enzymes of bacteria necessary for their reproduction. Interfering with the growth and reproduction of bacteria is called a bacteriostatic effect, however, in high doses, the drug can be bactericidal, that is, destroy bacteria.

Due to its chemical composition, drug resistance rarely develops. In addition, cross-resistance with fluoroquinolone drugs is also quite rare. All this makes it necessary to leave levofloxacin as a backup method of fighting infection, when other drugs, to which resistance has already begun to develop, cannot cope.

Levofloxacin has a number of serious side effects and, in this regard, a number of contraindications. The pathological effect of the drug on tendons and cartilage has been proven, so the drug is contraindicated in the following people:

• Those with a history of tendon injury as a result of taking fluoroquinolones.
• Children under 18 years old.
• Pregnant.
• Nursing.

The drug has a certain effect on the central nervous system, therefore its use is limited among people with epilepsy, increased epileptic readiness of the brain, as well as myasthenia gravis and other diseases associated with the central nervous system.

It was revealed that a rapid intravenous infusion of levofloxacin leads to a sharp critical decrease in blood pressure. In this regard, if intravenous administration of the drug is necessary, it should be infused slowly, over 60-90 minutes.

Due to its high efficiency, the use of the drug is possible even in people with a high risk of side effects. In this case, the possible consequences should be less significant than the disease against which levofloxacin is used.

Amoxiclav

Amoxiclav is combination drug. It consists of two active substances that complement each other. The drug is an antibiotic of the penicillin series, since it contains amoxicillin.

It has long been known that there are a number of bacteria that produce beta-lactamase, which can destroy penicillin. To combat such bacteria, a beta-lactamase inhibitor is added to the composition of simple antibiotics, which significantly increases the effectiveness of the drug.

Amoxiclav is one such antibiotic. In addition to amoxicillin, the composition contains clavulanic acid protecting the main active substance from aggressive bacteria. Clavulanic acid allows you to expand the spectrum of the drug, by using it against those bacteria that are usually resistant to penicillins.

The drug is available in two main forms: tablets and powders. Powders can be both for the preparation of suspensions for oral administration, and for solutions for intravenous administration.

The mechanism of action of amoxiclav is based on the fact that it stops the growth of the bacterial cell wall. As a result, the framework becomes unstable, becomes thinner, and then the bacterium lyses, that is, it dies.

There are no highly specific contraindications for taking amoxiclav. It should be used with caution in persons with chronic or acute diseases of the liver and gastrointestinal tract. Pregnant women are prescribed the drug only if the threat to the mother outweighs the threat to the child from taking the antibiotic.

Similarities and differences

Levofloxacin and amoxiclav are drugs of different pharmacological groups and generations. However, their scope is quite similar, since they are more often prescribed in cases where classical penicillins do not work.

The choice of a particular drug depends, first of all, on the sensitivity of the bacteria. According to the spectrum of action, both drugs are quite similar, so you should choose based on indications and contraindications.

At the age of 12 to 18 years, amoxiclav will be the drug of choice, since it is quite difficult to justify the use of levofloxacin in children. Penicillin will also be more preferable in the treatment of pregnant and lactating mothers, despite certain contraindications.

Restrictions on the use of these antibiotics practically do not overlap, so the choice of a specific one will be based, firstly, on the sensitivity of bacteria, and secondly, on the presence of contraindications to one of them in the patient.

Scope and what to choose

Levofloxacin is widely used in ophthalmology both in the form of drops and as a systemic antibiotic. In addition, the drug successfully copes with complicated bronchitis and pneumonia. It has been proven effective against diseases such as anthrax and tuberculosis. It has also found wide application in the treatment of the genitourinary system:

• Prostatitis.
• Tubulointerstitial nephritis.
• Urinary tract infection of unspecified localization.

Amoxiclav is often used for ear infections of the nasopharynx:

• Acute sinusitis.
• Acute pharyngitis.
• Acute suppurative otitis.
• Acute tonsillitis.
• Chronic otitis, sinusitis, pharyngitis, tonsillitis.

The drug is used in gynecology, urology, as well as orthopedics, for the treatment of osteomyelitis and other diseases of the musculoskeletal system.

The choice of the best remedy is based on the disease to be treated. In the treatment of pathology of the upper respiratory tract, Amoxiclav will be much more effective, but it will be useless for ophthalmic diseases. In addition, amoxiclav remains the drug of choice in the treatment of children and pregnant women. Levofloxacin should be chosen in extreme cases of bronchitis and pneumonia, as well as in rare infectious diseases.

Broad-spectrum antibiotics help fight a large number of infectious diseases. Cifran instructions for use describes how a combined antibiotic that is effective against a large number of microorganisms.

Ciprofloxacin, what kind of antibiotic

Cifran combines two antibiotics - ciprofloxacin and tinidazole. It is a broad spectrum antibiotic. It belongs to the group of fluoroquinolones. Cifran works by suppressing DNA gyrase and inhibiting DNA synthesis in bacteria.

Effective against most groups of gram-negative microorganisms. It also affects all microorganisms producing β-lactamase. It is used in the treatment of amoebic and bacterial mixed infections, as well as in the combination of aerobic and anaerobic flora.

The main advantage of this drug is that it is rapidly absorbed when taken orally. It does not matter, the use of food, because it does not critically affect the rate of absorption. Bioavailability after administration - 70%. With plasma proteins, the connection reaches 40%.

Two hours after application, the maximum concentration of the active substance is observed. Excretion of residues is carried out by the kidneys. Most of it is excreted in the urine, but a certain percentage of the residual substances are excreted through the intestines.

Penetrates into the cerebrospinal fluid. Its concentration there depends on the presence of inflammation. If the membranes of the spinal cord are inflamed, then it is up to 40%.

Indications for use:

1. Postoperative infections.
2. Bacterial infections of the abdominal cavity.
3. Respiratory tract.
4. Acute and subacute conjunctivitis.
5. Infections after trauma to the eyes and cornea.
6. Support for immunosuppressed patients.
7. Infectious lesions of the joints, bones and skin.

The drug must be used after consulting a doctor.

Important! Taking antibiotics that you self-prescribe can be dangerous to your health.

Tsifran and all its types

Cifran is produced by the largest pharmaceutical company in India, Ranbaxi Laboratories Limited. It contains several components, but the active active ingredient is ciprofloxacin hydrochloride. The film coating on the tablets contains purified talc, water and Opadray-OY-S58910.

The excipients are magnesium stearate, corn starch, cellulose, purified water and anhydrous flint.

Release form - film-coated tablets. There are two main types of drug:

1. Extended-release (OD) tablets contain nothing but ciprofloxacin and can be taken once every 24 hours. This form completely inhibits the ability of disease-causing bacteria to grow and multiply. 1 tablet contains 1000 mg of the active substance. This type of drug is produced in 5 pieces in a blister. Number of blisters 1 or 2 per pack.
2. The combined drug CT also contains a second active substance - tinidazole. One tablet of the drug contains 500 mg of ciprofloxacin and 600 mg of tinidazole. In the package from 1 to 10 blisters, each of which contains 10 tablets.

A dosage form is also available in the form of eye drops and a solution for injections.

Solution for injection is available in ampoules containing 200 mg of ciprofloxacin per 100 ml of solution.

Eye drops. One bottle of 10 ml contains 30 mg of active ingredient. In addition, there is an eye ointment that is used for infections of the eyelids and bacterial infections of the cornea.

Indications for use

Cifran tablets are prescribed by a doctor and are effective in the following pathologies:

• Mixed and dysentery infections of the gastrointestinal tract.
• Gonorrhea.
• Respiratory tract infections, including those with purulent complications.
• Severe gynecological infections, including complications after abortion.
• It is used for sore throat, pyelonephritis, and many other infections.

The procedure for taking Cifran differs, depending on which form of release (OD or ST).

CT should be taken orally after meals with a glass of clean water. Tablets should be swallowed whole, without breaking or chewing. The dosage is as follows: for an adult patient 500 + 600 mg 2 times a day., You can 250 + 300 mg, two tablets every twelve hours. The course of treatment is 10-14 days.

Receiving OD. Depends on the specific infection and the severity of the disease:

• Gonorrhea. If acute - once a day, once a day, 500 mg. Acute complicated - once a day, 500 mg for up to 5 days.
• Acute sinusitis. Once a day for 10 days, 1000 mg.
• Diseases of the urinary tract. Once a day for 2 weeks. If a difficult case is 1500 mg, in the rest - 1000 mg.
• Chronic bacterial prostatitis. For 28 days, 1000 mg once a day.
• Typhoid fever. 10 days, one tablet of 1000 mg once a day.
• Bone and joint infections. 1000 - 1500 mg once a day for up to 6 weeks.
• Infectious diarrhea - 5-7 days, 1000 mg.
• Respiratory tract infections. 1000 - 1500 mg for 2 weeks.

When prescribing this remedy, the specialist focuses on the performance of the kidneys, on the age and weight of the patient.

Useful video: about the diagnosis and treatment of prostatitis

Indications for the use of injections

Injections of the drug Tsifran are done intramuscularly or intravenously. The dosage depends on the severity of the infection and the characteristics of the patient's body. Injections are prescribed for people over 18 years of age. Children should not inject this substance.

The dosage is as follows:

1. Diseases of the upper respiratory tract - 100 - 200 ml 2 times a day
2. Cystitis - once 50 ml.
3. Diarrhea of ​​infectious breed - 100 ml 2 times a day. The course of treatment is a week.
4. Pulmonary form of anthrax - 200 ml 2 times a day.

Treatment with injections can last from 1 day to 2 months, but not longer, since the risk of side effects increases and the negative load on the kidneys increases.

Doctors prescribe the highest course for osteomyelitis. The average course is 7-14 days for most infections. If the solution is administered with a dropper, then a slight increase in the dosage of the antibiotic is allowed.

Digital for prostatitis

Antibacterial treatment is prescribed for prostatitis in the case when the inflammation of the prostate happened due to infection. Efficiency in this disease is confirmed by both clinical studies and the experience of many doctors.

The group of fluoroquinolones, to which Cifran belongs, has proven itself in the fight against bacterial prostatitis. With a non-bacterial nature of the disease, antibiotics should not be taken. Bacterial prostatitis can provoke bacteria of several groups:

• Gram-positive, such as staphylococcus aureus.
• Gram-negative - salmonella, E. coli.
• Intracellular - chlamydia, brucella.

The advantage of Cifran over other drugs is its rapid absorption, and also the fact that after a full course for a few more days the concentration of the active substance in the blood is high enough so that bacteria cannot multiply.

Treatment should be started as early as possible, as chronic prostatitis can lead to problems with potency and erectile dysfunction.

It is used both in the form of tablets and in the form of injections. The course of admission for chronic prostatitis is a week. Dosage per day - 250-500 mg. If we are talking about injections, then - 200-400 mg.

An increase in dosage is prescribed only by a doctor, in case of complications or an advanced stage of the disease.

The advantages of this drug for inflammation of the prostate gland are obvious:

• Destroys all bacteria, including inactive ones.
• Combines with other substances and does not affect them.
• Cheap compared to many similar products.
• Bacteria do not have time to get used to the antibiotic and it remains effective.

As a result, all the advantages make Ciprofloxacin a popular substance in terms of the number of prescriptions. Reviews of doctors and patients about the result of the action are positive. The disadvantages of the drug are common with other antibiotics, for example, dysbacteriosis. Therefore, the choice of Tsifran as a drug for the treatment of prostate infections is fully justified.

Useful video: the benefits and harms of antibiotics

Side effects and contraindications

Side effects of antibiotics are common, so you should consult your doctor before starting treatment. Only a doctor should prescribe a specific drug, as well as its dosage. Side effects can be in several body systems:

1. Gastrointestinal - nausea, diarrhea, vomiting.
2. Nervous system - fatigue, anxiety, dizziness, weakness, in rare cases, convulsions.
3. The cardiovascular system. Arrhythmia, fainting, pain behind the sternum.
4. Circulatory system. Decreased levels of red blood cells, platelets and white blood cells.
5. Allergic reactions of varying severity.
6. Hypersensitivity to ultraviolet radiation, so you should not be in the sun for a long time during treatment with the drug without special creams.

If any of the adverse reactions occur, you should immediately consult a doctor, he will either adjust the dose or cancel this remedy.

The remedy also has contraindications for use:

• pregnancy;
• age up to 8 years;
• blood diseases with inhibition of hematopoietic function;
• convulsions and epilepsy;
• lactation;
• mental problems;
• atherosclerosis and other disorders in the brain;
• allergy to the components of the drug.

In the presence of any contraindication, the medicine is not prescribed and is replaced by another antibiotic.

Analogues

In pharmacies, you can easily find several analogues of Ciprofloxacin, both domestic and imported. They are similar in composition, according to the principle of influence. There may be differences in price, as well as in the number of side effects.

Cifran or Levofloxacin

Levofloxacin belongs to the same group as the drug in question. Application depends directly on the type of pathogens. For example, Levofloxacin is more effective against pneumococci, as well as atypical pathogens.

In turn, Tsifran will show better results in the fight against Pseudomonas aeruginosa. Clinical trials have shown that a pathogen that does not respond to Ciprofloxacin may well be susceptible to Levofloxacin.

Important! Both drugs are well absorbed and do not react to food other than milk and its components.

Adverse reactions are similar for both drugs.

As for the price, here the buyers are on the side of Tsifran, since it is several times cheaper than its modern counterpart. In any case, Ciprofloxacin and Levofloxacin should be prescribed by a doctor, taking into account the individual characteristics of the organism and the complexity of the disease.

The doctor can change one drug to another if necessary, but the price category in any case will have to be taken into account.

Cifran or Tsiprolet

Both drugs contain the same active ingredient. Both drugs have a similar principle of action, side reactions, as well as contraindications. Therefore, you should not use them together, and the doctor should prescribe one of the antibiotics. Tsiprolet does not have a prolonged effect, like one of the Citrofan types.

Since the contraindications are also similar, patients who are not suitable for one of the remedies are also not recommended to prescribe the second. It should be noted that Tsiprolet is more easily tolerated by patients with gastrointestinal problems. The difference in price is insignificant, but there is. Digital is cheaper.

Cifran or Amoxiclav

Amoxiclav is more easily tolerated by the body and produces fewer side effects. Cifran has a wider spectrum of action and can fight Pseudomonas aeruginosa, against which Amoxiclav is powerless. Ciprofloxacin is more effective for the elderly, while the analogue has a more convenient form of release - suspension.

Other analogues

There is more than one drug that is considered an analogue of Tsifran and can successfully replace it:

1. Nolicin is a medicine from Slovenia from the group of fluoroquinolones. The active substance is norfloxacin. Can be taken at the same time, but under medical supervision.
2. Ofloxacin - is available only in the form of tablets, the active substance is Ofloxacin. The dosage is prescribed strictly individually.
3. Doxycycline is a group of tetracyclines. It has a much milder effect on the intestinal microflora. It differs in the principle of exposure, since it does not affect the DNA of bacteria, but the proteins of protein cells.

When choosing, you need to pay attention not to personal preferences, but to the advice of a doctor. Any antibiotic should be taken only on the advice of a specialist.

Useful video: effective treatment of prostatitis in men

Conclusion

Antibacterial drugs filled the shelves of pharmacies. There are new generations of tools that are more effective. Broad-spectrum antibiotics from the group of fluoroquinolones can affect a huge number of different groups of bacteria.

Therefore, Ciprofloxacin is effective in a large number of infectious diseases, including prostatitis. But the doctor must prescribe the medicine strictly, based on the specific situation.

Tavanic is an antibiotic with a wide therapeutic effect. It is able to cure many infectious diseases, the pathogens of which are sensitive to levofloxacin.

It copes well with acute sinusitis, bronchitis, pneumonia, as well as infections of the genitourinary system.

Manufacturer and release form

The original drug Tavanic is produced by the German company SANOFI-AVENTIS.

There are two dosage forms in pharmacies:

• covered with a soft yellow-pink shell, biconvex tablets with dividing grooves. Packed in 3/5/7/10 pieces;
• sterile transparent greenish-yellow injection solution placed in glass vials (100 ml).

The active substance is the antibiotic levofloxacin. Tablets may contain 250 or 500 mg, which is indicated on their packaging. In a vial with a solution (100 ml) there is also 500 mg of an antibiotic.

The tablets additionally include:

• crospovidone;
• hypromellose;
• cellulose;
• titanium dioxide;
• talc;
• macrogol 8000;
• red/yellow iron dioxide.

The injection solution also contains:

• hydrochloric acid;
• sodium hydroxide/chloride;
• water (deionized).

Therapeutic effect and scope

Levofloxacin, like all systemic quinolones belonging to the 3rd generation, has a wide range of therapeutic effects.

It disrupts the DNA structure of harmful microorganisms, causing strong changes in the cytoplasm, cell walls, which leads to their death. By killing pathogens, the drug successfully fights the inflammatory processes caused by them.

Tavanic is effective for:

• sinusitis (acute);
• inflammation of the lungs;
• bronchitis;
• urinary tract infections;
• bacterial chronic prostatitis;
• infectious skin diseases;
• sepsis;
• intra-abdominal infections.

Instructions for use, features of the reception

The daily dose of the drug for almost all diseases is 250/500 mg, taken 1 to 2 times.

Tablets are swallowed whole with water (0.5 - 1 cup). It is not recommended to bite or chew them. If it is required to take half of the tablet, it is divided using the dividing groove. Absorption of the drug into the blood occurs quickly and completely.

The intake of Tavanic does not depend on the intake of food. It can be drunk at any time. But if complex therapy is carried out, then with joint treatment with antacids or iron-containing drugs, as well as Sucralfate, the interval between their intake and Tavanic should be 2 hours.

The injection solution must be given slowly. At least one hour should be allowed for the complete introduction of one vial. It is not recommended to store such a preparation in conditions of strong illumination for more than 3 days.

Intravenous administration of Tavanic is allowed along with solutions:

• physiological;
• dextrose (5%);
• Ringer with dextrose (2.5%);
• nutritious (carbohydrates + trace elements + amino acids).

But the simultaneous injection with a solution of sodium bicarbonate is prohibited.

Injections are recommended for severe forms of the disease. When the patient's condition improves, the injection of the solution is replaced by taking tablets. If the patient's body temperature returns to normal, then after 3 days the antibiotic is canceled.

During treatment, you can not visit the solarium, you should avoid direct bright sun and ultraviolet radiation. Long-term use of the drug sometimes causes dysbacteriosis, a weakened body can undergo a fungal infection.

These negative properties of Tavanic are easily removed by co-administration with Bifidumbacterin, Linex, antifungal agents. The dose of the drug depends on the nature / severity of the disease, as well as on the presence / absence of renal failure.

For patients who do not have kidney problems, daily dosages are as follows:

• sinusitis (acute) - 500 mg / 1 time / 1.5-2 weeks;
• chronic bronchitis (exacerbation) - 250-500 mg / 1 time / 7-10 days;
• pneumonia - 500 mg / 2 times / 1-2 weeks;
• urinary tract infections (uncomplicated) - 250 mg / 1 time / 3 days;
• bacterial prostatitis (chronic) - 500 mg / 1 time / 4 weeks;
• skin infections - 250-500 mg / 2 times / 1-2 weeks;
• sepsis - 500 mg / 2 times / 1.5-2 weeks;
• infections of retroperitoneal organs - 500 mg / 1 time / 1-2 weeks;
• tuberculosis (treatment of resistant forms as part of the complex) - 500-1000 mg / 2 times / 3 months.

For people with renal insufficiency, the first dose of the drug should be taken in accordance with this table, and subsequent doses should be taken at half the dosage. If during treatment the Tavanica tablet was not drunk on time, it should be taken as soon as possible, and then follow the established scheme.

Older people who do not have kidney problems can use this medicine at the usual dosage. But children should not be given it, since levofloxacin can disrupt the growth of cartilage tissue, which will make the joints fragile.

With great care, the drug is prescribed to people prone to convulsions. This group includes persons who have undergone:

• stroke;
• head injury.

Side effects

Sometimes with prolonged use of Tavanic, pseudomembranous colitis may develop (a symptom is diarrhea with blood).

In this case, treatment with the drug should be stopped and the elimination of the "side effects" should be dealt with. Rare cases of tendinitis threatening tendon rupture have been observed.

If this happens, the drug should be stopped immediately. If there are malfunctions in the nervous system, you should also stop using this drug.

Since Tavanic sometimes has an effect on the central nervous system, which manifests itself in drowsiness, dizziness, slowing down the reaction, while taking it, you can not drive vehicles, engage in other activities that require concentration.

Overdose

Taking an excessive dose of the drug can lead to:

• confused mind;
• dizziness;
• hallucinations;
• convulsions;
• tremor;
• nausea, other digestive disorders;
• erosion of the gastrointestinal mucosa.

If these symptoms appear, you should wash the stomach and take antacids.

With prostatitis

This drug is very effective in the fight against bacterial prostatitis, especially in combination with a special diet, prostate massage, and other physical procedures.

During a long 4-week course, patients should take 500 mg of the drug once a day. The success of treatment is assessed by examining prostate secretions.

If you want to speed up the treatment process, and the patient has no special contraindications, the doctor may prescribe another treatment regimen:

• the first week - 1000 mg / day;
• the next 10 days - 500 mg / day.

As a result, the course of treatment is shortened to 2.5 weeks. In the treatment of acute prostatitis, the first half of the course should be injected with the drug, and then proceed to taking pills.

In the chronic course of the disease, you can limit yourself to only the tablet form of Tavanic. The drug enters the prostate rather quickly and in large volume, outperforming many antibiotics used in the disease of this organ.

For cystitis and chlamydia

In uncomplicated (without blood / pus in urine) acute cystitis, the drug should be drunk for 3-5 days. 250 mg once a day. In chronic cystitis and the presence of complications, the same dose of medication should be taken for 1.5-2 weeks.

With the genital form of the disease, take 500 mg of Tavanic for 10 days. The pulmonary form, which causes pneumonia, requires intravenous administration of the same volume of medication for 7-10 days.

Alcohol compatibility

Ethanol increases the likelihood of a "side effect", while reducing the therapeutic effectiveness. Therefore, you should refuse to use it for the entire period of treatment.

Contraindications

Tavanic has a number of absolute contraindications, in which its use is unacceptable, and relative - in which the drug should be taken with caution.

Absolute is the presence of:

• epilepsy;
• tendinitis;
• pregnancy;
• age less than 18 years;
• allergic reaction to Tavanic.

Consider relative:

• predisposition to seizures;
• renal / heart failure;
• low magnesium/potassium levels;
• taking sugar-lowering drugs;
• the presence of pseudoparalytic myasthenia gravis.

Related videos

Reviews of the doctor about the drug Tavanic:

Tavanic is an effective antibiotic that confidently copes with pathogens of many diseases. But it can also cause unwanted reactions. Therefore, only a doctor should prescribe it.

Kanefron (tablets): composition, principle of action of the drug, indications and features of use

In the vast majority of cases, physicians are wary of herbal medicine, preferring stronger drugs with proven activity and clinical experience.

However, the effectiveness of Canephron (tablets) has been confirmed by its long-term use for the treatment of various diseases of the urinary system.

Moreover, this medicine in the form of dragees or drops is recommended both for their therapy (usually in combination with other medicines) and for prevention.

Until recently, the use of medicinal plants was mainly limited to taking infusions and decoctions prepared at home. But patients usually do not attach due importance to the principles of herbal storage, make mistakes in dosage and manufacturing technology. This simply nullifies the effectiveness of such treatment. Such flaws are excluded when using a ready-made phytopreparation - Kanefron tablets.

However, when appointing them, the following rules must be observed:

1. In the acute period, dragees are taken only with antibiotics or uroseptics.
2. Combinations with other drugs should be selected carefully, taking into account the possible effect on efficacy and the risk of complications.
3. Accurately calculate the dosage, which depends on age and the presence of concomitant diseases.
4. The course of treatment should be long enough to provide the desired effect, but not very long due to the likely risk of developing resistance of the pathogenic flora of the urinary tract to the action of the drug.

With an adequate selection of the dose and combination with an antibacterial drug, Kanefron tablets enhance and maintain the antimicrobial activity of the antibiotic for a certain time (essential oils destroy the membrane of a pathogenic cell). At the same time, the phytopreparation is devoid of serious side effects that antibacterial drugs have. First of all, it is a negative effect on the digestive and immune systems.

In addition, Kanefron tablets have the following additional effects:

WE ADVISE! Weak potency, a flaccid penis, the absence of a long-term erection is not a sentence for a man's sexual life, but a signal that the body needs help and male strength is weakening. There are a large number of drugs that help a man get a stable erection for sex, but they all have their drawbacks and contraindications, especially if the man is already 30-40 years old. Capsules "Pantosagan" for potency not only help to get an erection HERE AND NOW, but act as a prevention and accumulation of male power, allowing a man to remain sexually active for many years!

• diuretic due to the improvement of blood flow in the kidneys and the acceleration of filtration in the glomerular system;
• antispasmodic and, as a result, analgesic;
• anti-inflammatory;
• nephroprotective;
• stimulates the release of uric acid salts and normalizes the pH of urine, that is, it affects the main causes of urolithiasis.

Kanefron (tablets) are safe for almost all categories of patients, since the drug contains only herbal ingredients. It:

• Herb centaury (Centaurium umbellatum) contains bitterness, flavonoids, alkaloids and other useful substances. It has a moderate antibacterial activity against the main pathogens of urinary tract diseases, stops inflammation, normalizes the condition of the walls of blood vessels in the kidneys and stimulates diuresis.
• Lovisticum officinale root (Levisticum officinale) The plant owes its diuretic effect to a large amount of essential oils; in foreign medical articles, the antimicrobial activity of this plant is repeatedly emphasized.
• Rosemary leaves (Rosmarinus officinale) contain alkaloids and tannins, but their main constituent is essential oil, which stimulates blood flow in the renal vessels, promotes urine output, relieves spasm and symptoms of inflammation. But its main effect is a pronounced activity against almost all representatives of the pathogenic flora of the urinary tract, in particular, staphylococcus and streptococcus.

First of all, Kanefron tablets act on neurotropic bacteria, even those that form a protective film. Also, the components of the drug relieve spasm of the urinary tract, activate the emptying of the bladder from residual urine, which is an excellent breeding ground for the development of bacteria.

Also, Kanefron tablets have a therapeutic anti-inflammatory effect, stopping the synthesis of leukotrienes, prostaglandins, cytokines, toxic enzymes and other mediators that stimulate swelling and pain. The manufacturer of the drug is a German company specializing in the production of herbal medicines, Bionorica.

The main principle of the corporation's work is phytoneering, that is, a strictly scientific approach and the use of modern technologies in order to get the maximum effect from a combination of plant components. For ease of administration at any age, Kanefron is produced in the form of tablets and solution (drops).

According to the annotation, indications for the use of the drug are:

• cystitis;
• pyelonephritis;
• uric acid diathesis (the presence of sand in the kidneys or bladder);
• recovery after removal of stones (by any method);
• inflammation of the kidneys of non-bacterial etiology (for example, glomerulonephritis or interstitial nephritis);
• treatment and prevention of recurrence of urolithiasis.

In the presence of microbial flora in the acute phase of the inflammatory process, Canephron tablets are used only in combination with basic antibacterial therapy.

Most patients do not experience any complications while taking the drug. With a tendency to allergic reactions, itchy rashes on the skin may appear. The components that make up the drug stimulate the digestive tract, so patients may experience nausea, less often vomiting or diarrhea.

If blood appears in the urine, acute pain in the lower abdomen, you should immediately stop taking Kanefron tablets and consult a doctor.

Contraindications to the appointment of the drug are:

• hypersensitivity, both to the main ingredients of the drug and to auxiliary components (including sucrose, lactose, castor oil);
• stomach ulcer during an exacerbation;
• edema, provoked by pathologies of the cardiovascular system.

Patients with diabetes should take Canephron tablets with caution, as their shell contains a small amount of sucrose. In addition, the drug is categorically contraindicated for monotherapy of renal failure.

Kanefron: instructions for use, tablets and drops

In accordance with the instructions for use, the dosage of Kanefron tablets is standard and does not depend on the disease. When the first symptoms appear, 2 tablets are prescribed three times a day. Moreover, the drug should be continued for at least 2-4 weeks after the disappearance of all clinical manifestations of the pathology.

But it is worth paying attention that with cystitis Canephron is recommended to be taken only in combination with uroseptics. The fact is that the antibacterial activity of the plant components of the drug may not be enough to suppress the pathogenic microflora, and this is fraught with the transition of the disease to a chronic form. A combination of an antibiotic, uroseptic, antispasmodic, or analgesic is usually prescribed.

Antibacterial drugs prescribed for cystitis include:

• cephalosporins II - III generation (Zinnat, Ceklor, Suprax, Cedex), the dosage is calculated individually, in some cases the maximum allowable amount of the drug is required;
• fluoroquinolones (ciprofloxacin, levofloxacin);
• penicillins (Augmentin, Amoxiclav), usually used for the first episode of cystitis;
• uroseptics, often prescribed fosfomycin (Monural), furazidin (Furamag).

In severe cases of cystitis, an antibacterial agent and Canephron tablets are combined in a dosage according to the instructions for use. Doctors emphasize that the effectiveness of the herbal remedy is not enough to eliminate edema of renal etiology. Additionally, diuretics are prescribed (Lasix, Mannitol, Veroshpiron, Triamteren). In addition, it is necessary to treat the underlying disease, which provoked the development of such symptoms.

With edema of renal origin, Canephron tablets are taken according to the instructions for use - 2 tablets three times a day. Pathology of the urinary system often occurs in childhood. In girls, this is usually associated with poor perineal hygiene, with the bacterial flora spreading via an ascending pathway after vulvovaginitis. This is often the cause of not only cystitis, but also pyelonephritis.

Sometimes such pathologies are due to congenital structural features of the pelvic organs. At an early age, inflammatory diseases of the urinary tract have a tendency to frequent relapses. Kanefron will help to avoid prolonged use of antibiotics and other synthetic medicines. Unlike adults, it is dangerous to give pills to a child, so doctors recommend using drops. They are more convenient and safer in terms of dosage.

Kanefron tablets are contraindicated for the treatment of diseases of the kidneys and bladder for children under 6 years of age.

The dosage of the solution is 15-25 drops (depending on age) three times a day. Children under 3-4 years of age should use the drug with caution due to the ethanol content. A positive property of Kanefron tablets is the possibility of use during pregnancy and lactation.

Gynecologists often prescribe this medication to women with a history of kidney disease and cystitis, when urolithiasis is detected, to prevent and as part of complex therapy for preeclampsia in a standard dosage. Dragee should also be taken up to 2 weeks after childbirth. As a prophylactic, the amount of the drug is reduced to 2 pills per day (morning and evening). However, self-administration of Canephron tablets, even according to the instructions for use, and combination with other drugs is unacceptable.

Canephron medicine: analogues, cost, reviews

In addition to Canephron medicine, doctors may suggest other herbal remedies. The most common is cystone. The composition of this herbal remedy is more diverse. It contains more than 10 active ingredients.

Among them:

• Flowers of the stalk bicarp. The plant regulates calcium metabolism and increases the effectiveness of urolithiasis therapy. It also has antimicrobial activity.
• Grass saxifrage reed. In folk medicine, it is widely used as a bactericidal and anti-inflammatory agent.
• Grass madder cordifolia. Usually they use infusions and decoctions from the roots of the plant, ignoring its aerial part. Leaves and stems of madder remove toxins and have a general tonic effect.
• Rhizomes of saty membranous. It has long been used in oriental medicine as an anti-inflammatory and antiseptic agent.
• Rough strawflower seeds have a diuretic, antispasmodic, antipyretic and antimicrobial effect.
• Flowers, leaves and stalks of osma pariflorum, contribute to the speedy healing of the epithelium of the ureters and urethra damaged after the passage of the stone, and has a general tonic effect.
• Vernonia ashy (whole plant) is known for its antibacterial activity.
• Mummy. Many people note the stimulating and tonic effect of this remedy; with prolonged use, mumiyo strengthens the immune system and increases the body's resistance to various pathogenic factors.

The indications for taking Cyston are the same as for Canephron. With urolithiasis, it is taken 2 tablets three times a day for six months or until the stones are completely removed from the kidneys.

After surgical removal of calculi, Cyston is drunk in the same dosage for a month, then 1 tablet twice a day for another 5 weeks.

For bacterial urinary tract infections, it is also prescribed in combination with antibiotics. The course of treatment is up to 3 months in the amount of 2 pills 2-3 times a day. Taking Cyston, like Canephron medication, is not contraindicated during pregnancy and breastfeeding. But this drug is produced only in the form of tablets, so its use in childhood is limited.

Another herbal preparation for the treatment of various diseases of the urinary tract is Phytolysin, which contains:

• goldenrod grass, stimulates metabolic processes, removes toxins and has a general anti-inflammatory effect;
• horsetail grass, a diuretic known in folk medicine;
• herb Knotweed (knotweed), fenugreek seeds and couch grass rhizomes, regulate salt metabolism, contribute to the prevention and slow dissolution of kidney stones;
• onion peel, relieves spasm of the urinary tract, has a slight bactericidal and diuretic effect;
• birch leaves, parsley root have a diuretic and antiseptic effect.

In addition, Phytolysin contains general tonic ingredients - peppermint, pine, and orange oil. The disadvantages of the drug include the release form, it is produced in the form of a paste, which is not convenient for everyone to take. The Ukrainian pharmaceutical company has relatively recently mastered the production of a complete analogue of the drug Canephron - Trinefron. But to date, the drug has not been registered in Russia, although it costs less than the original medication.

As for the price of Kanefron for a package containing 60 tablets, you will have to pay about 450 rubles, for a bottle of drops (100 ml) - 430 rubles. Reviews of patients after therapy with this phytopreparation are overwhelmingly positive. This is especially true for the treatment of young children. When observing the child during the year, not a single case of relapse was detected. But doctors draw attention to the fact that the effect of Canephron, like any other herbal medicine, develops slowly. Therefore, it is important to observe the dosage and mode of application.

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